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The ITC was performed using the Bucher method, which accounts for cross-trial differences by measuring treatment effects relative to a common comparator arm (in this case, dulaglutide 1.5 mg) and requires only the availability of summary-level data for each trial [18]

Reviewer 1 While the authors quantified cell proliferation of (or rather density of proliferating) RGL-NSCs and IPCs 3 weeks after TAM using EdU to label proliferating cells, this is an (understandably) narrow outcome measure in that it only assesses EdU labeled cells

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