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The FEBS Journal 2023;290, 1362-1383, doi: 56

Studies reveal that the peptide disrupts the FOXO4-p53 interaction, inducing apoptosis in senescent Leydig cells and restoring testicular homeostasis (6)

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The cagrilintide dosage schedule can be modified based on individual response, but adjustments should be made systematically: Extending escalation intervals (e.g., 6 weeks instead of 4) is acceptable and often beneficial for those experiencing persistent side effects