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Include fiber from whole food sources rather than supplements, which can worsen the feeling of fullness

Patients with type 2 diabetes who are overweight may find Semaglutide GLP-1 to be a useful therapy choice because of its ability to help patients lose weight

The SURMOUNT-1 trial for tirzepatide showed average weight loss of 15 to 22 percent of body weight across the full study population

Safety Considerations and Future Outlook As with all pharmacotherapy for obesity and T2D, establishing cardiovascular safety and demonstrating improvements in meaningful clinical outcomes will be essential, particularly as cardiovascular outcome trials have not yet been completed with multi-agonists (although data are expected soon for tirzepatide: SURPASS-CVOT [T2D] in 2025

Sjlund, K., Sandn, G., Hkanson, R

However, participation involves: Strict eligibility screening Ongoing monitoring Possible placebo allocation Defined study duration Clinical trials are research studies, not guaranteed treatment pathways