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The cardiometabolic data also reinforce the emerging understanding that incretin-based therapies produce benefits beyond weight loss itself likely through direct receptor-mediated effects on hepatic metabolism, vascular inflammation, and lipid handling
The protective effects of adenosine are mediated by A2A receptors that can be found on virtually all immune cells [77]
The timing strategies that worked at the lower dose may need small adjustments at the higher dose
GLP-1-induced insulin synthesis is initiated by Pdx1
doi: 10.2337/db15-1224
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