However, retatrutide may have superior benefits for insulin resistance and glycemic regulation , due to: Enhanced insulin sensitivity from GIP agonism Reduced hepatic glucose output from glucagon signaling modulation Improved beta-cell function Clinical Insight: Retatrutide reduced fasting glucose and A1C levels with similar or better efficacy than tirzepatide in early trials
[DOI] [PubMed] [Google Scholar] 24.Calcerrada P, Peluffo G, Radi R
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