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J Clin Invest 133(3):e167952 Kusminski CM, Perez-Tilve D, Mller TD, DiMarchi RD, Tschp MH, Scherer PE (2024) Transforming obesity: The advancement of multi-receptor drugs

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Comparing clinical results In major phase-3 trials submitted to NICE, tirzepatide users achieved average body-weight reductions of around 20 22 percent, compared with 15 percent typically seen in semaglutide studies