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Vitamin B12 functions in the body through two bioactive coenzymes: Methylcobalamin Functions in the cell plasma as a coenzyme in the methylation cycle Adenosylcobalamin Functions in the mitochondria as a coenzyme in the citric acid cycle Through these two functional mechanisms, multiple effects take place in diverse biological systems as explored in our article: Vitamin B12 Benefits The focus of this article is on methylcobalamin and its working within the methylation cycle

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The high degree of TH/GLP-1R overlap in the AP, together with the presence of semaglutide in these neurons (Figure 5), suggests a direct action of the 2 GLP-1RAs on GLP-1R/TH neurons in the AP

This creates a gap between formal scientific evidence and lived experience

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