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No supplement, including resM, has demonstrated weight loss results anywhere near the 15-20% body weight reductions achieved by tirzepatide and semaglutide in large randomized trials

Are There Any Risks or Downsides

Link administration to an existing habit (morning coffee, evening skincare routine)

80,81 Additionally, it is theorized that combining PDE inhibitors with GLP-1 RAs may provide additive benefits in metabolic and cardiovascular contexts in aging models, although supporting human data remain limited

What are the supposed benefits

For instance, in 3xTg-AD mice, sex-specific alterations in brain bioenergetics have been observed: females showed impaired complex I activity in synaptic cortical mitochondria, while non-synaptic mitochondria exhibited enhanced complex IImediated respiration (Stojakovic et al., 2021)