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the three conditional equilibrium constants are in equations (1)(3), (the symbols in square brackets mean total concentration, which actually are the sum of the concentration of all microspecies of the compound in question): In order to get a clear insight into the redox equilibria, purified from the protonation effects, an improved evaluation method was introduced to determine the species-specific redox equilibrium constants ( k 1 , k 2 , k 3 ) 14

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All calculations were performed using curated and standardized libraries from DB, FDB, Biosynth, Molport and Enamine

doi: 10.1212/WNL.0000000000001004 7

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Improvement in fibrosis by 1 stage, without worsening of steatohepatitis, occurred in approximately one-third of semaglutide-treated patients, compared with approximately one-fifth of those receiving placebo, corresponding to an absolute difference of 12-15 percentage points and an NNT of ~6-8