By design, DECLARE-TIMI-58 had the lowest CV risk cohort and the highest baseline mean estimated glomerular filtration rate (eGFR) of the three trials [32]
This is often particularly aimed at stabilizing the active conformation of the peptide, as cyclization imparts conformational constraint which reduces the entropic cost of binding, resulting in stronger, more selective target interactions (Zorzi et al., 2017
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for this reason, plastids are considered the site of GSH production in higher plants (Pasternak et al
doi: 10.1017/S1461145707008401