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While most peptide research programs begin with a specific therapeutic target and build a synthetic molecule to match, this compound emerged from a fundamentally different direction: isolation and characterization of a naturally occurring protective sequence, followed by decades of systematic investigation into its biological activity profile

Additional sources of O 2 generation come from nicotinamide adenine dinucleotide phosphate oxidase (NADPH) [15], nitric oxide synthase in peroxisomes [20], neutrophils (oxidative burst) [21], lysosome and microsomes [22,23]

While this oxidative burst is necessary for survival, it rapidly consumes the body's available glutathione