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However, limitations include in vivo instability, reliance on biocompatible and robust carriers and restricted application procedures (local and direct)

What is missing: randomized controlled trials of systemic GHK-Cu supplementation measuring clinically relevant aging outcomes

242 Additionally, UNA modification at the siRNA terminus improves siRNA stability and silencing efficacy while considerably reducing off-target effects, highlighting its potential in the development of new therapeutic siRNAs

385 , 503515 (2021) B

It is not approved for human use

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