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Conversely, loss of ROR disrupts bile acid rhythmicity, impairs FXRFGF15 signaling, reduces fatty acid oxidation, and produces severe hepatic steatosis, particularly under metabolic stress (44)

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These factors play a central role in the hair follicle cellular antioxidant response, orchestrating the transcription of various antioxidative enzyme genes (Peterle et al

It points out that many human trials have used very small sample sizes, usually between 17 and 80 people, which restricts the findings statistical power and potential to be applied to larger groups