Extending the incubation to 72 hours exacerbated these trends, and even GSH levels fell by 33%, and GSSG increased by 81% (Supplementary Figure 1g-l)
This HO-CO pathway has been recently proposed to be involved in the defence against oxidative stress and the deleterious effects of NO, since it removes the cytotoxic free heme, and produces some molecules with antioxidant and anti-inflammatory effects, such as biliverdin and CO [8, 3840]
10.1007/s11120-005-8425-1 30 MicheletL.ZaffagniniM.MarchandC.CollinV.DecottigniesP.TsanP.et al
Related compounds may include GLP-1S (Semaglutide), GLP-2T (Tirzepatide), and GLP-3R (Retatrutide)
Science 361 , eaat8235 (2018)
Lots of them, in fact, that can support you on your wellness journey as your estrogen and progesterone levels begin their rocky decline