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Most of the absorbed copper enters the liver through the portal vein and causes hepatoxicity [24]

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[12] Metformin: Anchor in the GLP-1 RA Care Continuum Journey The mechanistic, real-world, clinical trials and pharmacovigilance evidence landscape suggests metformin as the potential anchor pharmacological agent across the entire GLP-1 RA care continuum, during therapy and beyond.Table 1 summarises the key potential outcome benefits at each phase

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