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Nature 536 , 484487 (2016) Zheng, S

Retatrutide's Phase 2 trial data (Jastreboff et al., NEJM 2023) identified a side-effect profile broadly consistent with other incretin-based therapies: Gastrointestinal : Nausea, vomiting, diarrhoea, and constipation were the most commonly reported adverse effects, particularly during dose escalation

A closed conformational state of IRAP is created that is believed to be induced upon ligand binding

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Journal of Neuroinflammation Bharat S, et al

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