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105 Mechanistically, on the one hand, TMAO may promote cardiac remodeling in hemodialysis patients by accelerating myocardial fibrosis and myocardial hypertrophy

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Over weeks or months, this amount is increased in a step-wise method (often called titration) to help your body respond better while keeping side effects to a minimum

For some researchers, the additional weight loss from higher doses is not worth the increased side effect burden, and a dose between 1.0 and 1.7 mg represents their personal optimal balance

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