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TFs that we identified as regulating the most fragile enzymes and transporters are also validated by literature reports on TFs implicated in aging and neurodegeneration (see Presentation 1: Supplementary Information Files 18 ), and promising anti-aging therapies identified by this study are largely consistent with current understanding in the field
Antioxidant-Rich Diet : We recommend supporting your treatment with glutathione-boosting foods: cruciferous vegetables, garlic, onions, avocados, and high-quality proteins
10.1021/acs.jafc.8b07313 418 SunJ.PengS.YangQ.YangJ.DaiY.XingL
In the present study, we extend these findings by showing livers from GCLM KO mice exhibit a persistently greater level of oxidant stress as measured by protein carbonylation and expression of redox-sensitive genes
The GSH system, as a lipid peroxide scavenger, prevents the indefinite expansion of lipid peroxidation, which is a central step in hindering ferroptosis
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