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Pathophysiology of multiple sclerosis Multiple sclerosis is a complex pathology with continuous inflammatory activity within the CNS (Central Nervous System), giving rise to tissue damage that results in brain and spinal cord atrophy and irreversible neurological disability

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The same authors demonstrated that pretreatment with silymarin at a dose of 200 mg/kg/day for three days prior to APAP dosing, prevents decreases in GSH and ascorbic acid content

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This lead to a 200% rise in the cytosolic GSH levels (Figure 6A)

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doi: 10.1016/j.schres.2007.01.025 Gawlinska K, Gawlinski D, Przegalinski E, Filip M

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