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At the level of subcellular compartments, such as the nucleus, mitochondria, lysosomes, endoplasmic reticulum (ER), Golgi apparatus, etc., these perturbations are sensed and activate the corresponding signal transduction pathways to generate the appropriate biological response

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13 Further research is needed to investigate the interconnected pathophysiologic roles of glucagon, GLP-1, and GIP while determining the niche for twincretin therapy in T2DM

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