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Mistake 1: Too short a break

Reduction in Visceral Fat: Tesamorelin specifically targets and reduces visceral fat, which is linked to numerous health risks

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41,53 However, they are also distinct as successful second-phase insulin secretion requires synthesizing insulin and insulin vesicles, which are not thermodynamically favourable processes

Mol Neurodegener 15(1):30 Wang Z-J, Li X-R, Chai S-F, Li W-R, Li S, Hou M et al (2023) Semaglutide ameliorates cognition and glucose metabolism dysfunction in the 3xTg mouse model of Alzheimers disease via the GLP-1R/SIRT1/GLUT4 pathway

A separate Phase 2 trial in people with type 2 diabetes was also published in the NEJM in 2023, reporting meaningful reductions in HbA1c alongside weight loss