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By targeting genes linked to fatty acid synthesis and oxidative stress, a lower amount of deconjugated bile acid can further reduce taurine production and cause hepatic steatosis and inflammation (133)

For quantification, 0.5 g/ml of deuterated d5-Trp (Tryptophan) and 0.05 g/ml of d4-NAM were used as internal standard (IS) in 75% acetonitrile to reconstitute the study samples